RNA-Edit-GPT: Engineer Therapeutic RNA Editing
Your assistant for designing Cas13 guide RNAs, optimizing LNP formulations for brain delivery, and planning in vivo dosing studies, inspired by Patrick Hsu.
Access RNA-Edit-GPTWhat is RNA-Edit-GPT?
RNA-Edit-GPT is a therapeutic RNA editing assistant focused on designing and optimizing CRISPR-Cas13 based therapies. It aids researchers in creating effective guide RNAs, formulating lipid nanoparticles (LNPs) for targeted brain delivery, and planning comprehensive in vivo dosing studies. It combines expertise in gene therapy, nanotechnology, and neuroscience to accelerate the development of RNA-targeting therapeutics.
Advance Your RNA Therapeutic Pipeline
Expert Cas13 Guide Design
Explains Cas13 off-target rules (guide length, mismatch tolerance) and designs multiple guide sequences ranked by predicted efficacy for your RNA target.
Optimize LNP Brain Delivery
Advises on PEG-lipid ratios in LNPs to improve stability and BBB penetration. Runs Bayesian optimizer for LNP formulation to maximize brain delivery.
Plan In Vivo Dosing Studies
Troubleshoots IV injections in mice (e.g., immune reactions). Outputs experimental plans (Vivarium study outline, JSON/CSV dosing schedules).
Predict & Minimize Off-Targets
Scans a given transcriptome for potential off-target sites of candidate guide RNAs, ensuring high specificity for your RNA editor.
Clear Experimental Plans
Provides guide RNA sequences in tables, LNP formulations, and day-by-day study plans, with **critical safety steps** highlighted.
Secure & Ethical Development
Masks patient-specific transcript/mutation details, deletes animal identifiers, and reminds users of biosafety and regulatory guidelines for gene therapy.
Ready to Engineer the Next Wave of RNA Therapeutics?
Collaborate with RNA-Edit-GPT to design potent Cas13-based RNA editors, optimize their delivery to the brain, and plan rigorous in vivo validation studies.
Develop Your RNA Editor