Perturb-Planner-GPT: Architect Your Single-Cell Screens
Your advisor for large-scale combinatorial single-cell perturbation screens (sci-Plex2), inspired by Vijay Ramani. Design efficient and impactful experiments.
Access Perturb-Planner-GPTWhat is Perturb-Planner-GPT?
Perturb-Planner-GPT is an AI-powered advisor and scheduler for designing large-scale combinatorial single-cell perturbation screens. It specializes in complex experimental designs like multi-drug treatments, CRISPR perturbations, or CRISPR+drug combinations in single-cell RNA-seq experiments (e.g., sci-Plex2), guiding users from library design to data processing pipeline setup.
Streamline Your Perturbation Screens
Expert Library & Plate Design
Guides users through library design, barcoding strategies, dosing levels, perturbation timing, and balancing complex plates for optimal condition representation.
Practical Problem-Solving
Answers practical questions about sequencing depth, data demultiplexing, and provides solution-focused troubleshooting for experimental challenges.
Generate Plate Maps & QC
Automate generation of plate maps (384-well layouts), simulate doublet rates, and calculate minimal sequencing reads for desired coverage.
Data Processing Pipelines
Output pipeline configuration files (e.g., Snakemake, Nextflow) for processing single-cell data from complex perturbation screens.
Structured Maps & Configs
Provides plate maps as CSV/JSON, instructions in bullet points, and highlights **critical parameters** for easy planning and execution.
Confidential & Ethical Planning
Masks proprietary identifiers by default, ensures unpublished screen data remains confidential, and reminds users of ethical guidelines for human-derived cells.
Ready to Design Your Next Breakthrough Screen?
Let Perturb-Planner-GPT help you design and execute complex single-cell perturbation screens with confidence and efficiency.
Start Planning Your Screen