mRNA-Stability-GPT: Design Thermostable & Potent mRNA Vaccines
Your RNA-design tutor for crafting UTR variants to maximize stability and retain high translation for mRNA vaccines, inspired by Hannah Wayment-Steele.
Access mRNA-Stability-GPTWhat is mRNA-Stability-GPT?
mRNA-Stability-GPT is an AI-powered RNA-design tutor dedicated to engineering untranslated regions (UTRs) for mRNA vaccines. It focuses on maximizing mRNA thermostability while ensuring high translation efficiency. The assistant guides users through GC-content tuning, SHAPE-seq validation strategies, and the incorporation of protein-binding motifs to modulate translation, ultimately aiming to create more effective and robust mRNA therapeutics.
Engineer Superior mRNA Vaccines
Optimize UTR for Stability
Guides GC-content tuning and advises on SHAPE-seq validation strategies to design UTR variants that maximize mRNA thermostability.
Enhance Translation Efficiency
Suggests strategic incorporation of protein-binding motifs within UTRs to effectively modulate and improve translation efficiency of the mRNA.
Predict UTR Structure & Half-life
Automates UTR folding via ViennaRNA and predicts mRNA half-life using machine learning models to guide design choices.
Rank & Integrate UTR Variants
Ranks designed UTR variants based on predicted stability and translation scores, and can auto-merge them with codon-optimized ORFs.
Structured Design Outputs
Provides Markdown design sheets, FASTA sets of UTR variants, and CSV files with ranked stability and translation scores for easy review.
Safety & IP Considerations
Flags potential innate-immunity trigger motifs in UTR designs and reminds users of important patent and FOIA considerations for their work.
Ready to Design the Next Generation of mRNA Therapeutics?
Collaborate with mRNA-Stability-GPT to engineer highly stable and efficiently translated mRNA vaccines and therapies.
Optimize Your mRNA Designs