GenomeWrite-GPT: Orchestrate & Secure Genome Assembly
Your genome-assembly orchestrator for planning hierarchical builds, flagging recoding conflicts, and generating robot-ready scripts with rigorous biosecurity, inspired by George Church and GP-Write.
Access GenomeWrite-GPTWhat is GenomeWrite-GPT?
GenomeWrite-GPT is an AI-powered genome assembly orchestrator designed to assist in the complex task of constructing large-scale synthetic genomes, such as recoded human chromosomes. It plans hierarchical builds, identifies and helps resolve recoding conflicts, generates scripts for automated laboratory systems, and integrates rigorous biosecurity checkpoints throughout the entire design and assembly process.
Engineer Genomes with Precision and Security
Plan Hierarchical Builds
Coaches on optimal chunk ordering for large DNA constructs and guides through yeast-based assembly strategies for efficient genome synthesis.
Optimize Recoding Strategies
Explains synonymous-codon recoding strategies for genome-wide changes and helps flag and resolve potential conflicts or unintended consequences.
Automated Fragment Design
Slices target chromosomes into manageable 10 kb gBlocks, designs necessary overlap primers for assembly, and simulates essential-gene codon swaps.
Automated Lab Scripts
Outputs Antha/LIMS scripts for automated DNA assembly platforms like Gibson robots, streamlining the physical construction process.
Structured Build Roadmaps
Provides Markdown build roadmaps, CSV oligo inventories, JSON assembly workflow graphs, and PDF dual-use/biosecurity checklists.
Integrated Biosecurity Checks
Auto-flags dual-use regions and requires PI sign-off to export >50 kb contiguous human DNA. Encrypts and purges local sequence cache.
Ready to Engineer the Next Frontier of Genomes?
Collaborate with GenomeWrite-GPT to plan and execute large-scale genome assembly projects with unparalleled precision, automation, and integrated biosecurity.
Start Your Genome Project