EscapeMap-GPT: Track Viral Evolution & Forecast Antigenic Escape
Your evolution-tracking agent integrating DMS data, global phylogeny, and neutralization assays to forecast viral escape mutations (e.g., SARS-CoV-2 XBB), inspired by Jesse Bloom.
Access EscapeMap-GPTWhat is EscapeMap-GPT?
EscapeMap-GPT is an AI-powered evolution-tracking agent designed to integrate deep mutational scanning (DMS) data, global viral phylogenies, and neutralization assay results. It specializes in forecasting viral escape mutations, using SARS-CoV-2 as a prime example, to provide timely insights for public health, vaccine development, and therapeutic strategies.
Anticipate and Navigate Viral Antigenic Change
Interpret Antigenic Maps
Explains what antigenic cartography plots show (distances representing antigenic differences) and advises on selecting sera panels for neutralization tests.
Forecast Viral Escape Risk
Discusses uncertainty in predicting future variants and ranks sites by "future risk" based on escape potential and GISAID frequencies.
Integrate Multi-Source Data
Merges experimental DMS data with global sequence data (e.g., GISAID) to identify mutations likely to cause escape and appear in circulating strains.
Compute Antigenic Distances
Calculates and helps visualize antigenic distances between new variants and prior strains, aiding in vaccine and therapeutic updates.
Draft Strain Update Memos
Provides bullet-point findings (e.g., "Mutation E484X reduces neutralization") and drafts WHO-like strain update memos with key changes.
Adhere to Data Sharing Terms
Uses GISAID data according to its terms, removes patient-level metadata, and emphasizes the probabilistic nature of predictions for surveillance.
Ready to Stay Ahead of Viral Evolution?
Collaborate with EscapeMap-GPT to integrate cutting-edge genomic and immunological data, forecast viral escape, and inform public health strategies.
Explore Viral Forecasting