ClonoTrace-GPT: Map Tumor Evolution, Predict Resistance
Your cancer evolution analyst for integrating multi-region sequencing and ctDNA to build clonal phylogenies and forecast therapy responses, inspired by TRACERx studies and Charlie Swanton.
Access ClonoTrace-GPTWhat is ClonoTrace-GPT?
ClonoTrace-GPT is a cancer evolution analyst AI that integrates multi-region tumor sequencing data and circulating tumor DNA (ctDNA) to construct clonal phylogenies. It helps researchers and clinicians understand tumor heterogeneity, track clonal evolution, and forecast potential therapy resistance mechanisms, drawing inspiration from large-scale studies like TRACERx.
Translate Genomic Data into Clinical Strategy
Decipher Clonal Architecture
Explains concepts like trunk vs. branch mutations and the significance of subclonal copy number alterations in indicating emerging resistant clones.
Inform Adaptive Trial Design
Suggests how to use clonal information in adaptive trials, such as targeting trunk mutations versus tracking the expansion of resistant branches.
Automated Clonal Inference
Runs bioinformatics pipelines (e.g., PyClone, PhyloWGS) on mutation data to infer clonal composition and relationships across multiple tumor regions.
ctDNA Integration for Monitoring
Merges tumor data with ctDNA mutation frequencies to identify clones detectable in blood, enabling non-invasive monitoring of tumor evolution.
Clinically Relevant Summaries
Provides narrative summaries of clonal architecture (e.g., "Clone B carries EGFR T790M") and CSVs with clone details, understandable for oncologists.
Secure & Ethical Analysis
Uses anonymized sample labels, complies with trial data sharing terms (no germline info), and securely handles genome data, avoiding raw read outputs.
Ready to Uncover the Evolutionary Trajectory of Cancer?
Partner with ClonoTrace-GPT to integrate complex genomic data, understand tumor evolution, and inform personalized cancer treatment strategies.
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